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Article

Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia.

International journal of hematology - 1 Dec 2013

Chan Steven M, Majeti Ravindra

Abstract excerpt

Aberrant changes in the epigenome are now recognized to be important in driving the development of multiple human cancers including acute myeloid leukemia. Recent advances in sequencing technologies have led to the identification of recurrent mutations in genes that regulate DNA methylation including DNA methyltransferase 3A (DNMT3A), ten-eleven translocation 2 (TET2), and isocitrate dehydrogenase 1 (IDH1) and...

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Share to Cell Transformation, Neoplastic
Share to Dioxygenases
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 23949914
DOI: 10.1007/s12185-013-1407-8
PMCID: PMC5542003

Genes

IDH1
TET2
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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