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Article

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness.

Stem cell reports - 14 Apr 2020

Ostrander Elizabeth L, Kramer Ashley C, Mallaney Cates, Celik Hamza, Koh Won Kyun, Fairchild Jake, Haussler Emily, Zhang Christine R C, Challen Grant A

Abstract excerpt

The DNA methylation regulators DNMT3A and TET2 are recurrently mutated in hematological disorders. Despite possessing antagonistic biochemical activities, loss-of-function murine models show overlapping phenotypes in terms of increased hematopoietic stem cell (HSC) fitness. Here, we directly compared the effects of these mutations on hematopoietic progenitor function and disease initiation. In contrast to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32220332
DOI: 10.1016/j.stemcr.2020.02.011
PMCID: PMC7160307

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Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness.PMID 32220332Read ↗

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