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Article

c-Rel gain in B cells drives germinal center reactions and autoantibody production.

The Journal of clinical investigation - 1 Jun 2020

Kober-Hasslacher Maike, Oh-Strauß Hyunju, Kumar Dilip, Soberon Valeria, Diehl Carina, Lech Maciej, Engleitner Thomas, Katab Eslam, Fernández-Sáiz Vanesa, Piontek Guido, Li Hongwei, Menze Björn, Ziegenhain Christoph, Enard Wolfgang, Rad Roland, Böttcher Jan P, Anders Hans-Joachim, Rudelius Martina, Schmidt-Supprian Marc

Abstract excerpt

Single-nucleotide polymorphisms and locus amplification link the NF-κB transcription factor c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the functional consequences of enhanced c-Rel levels remain enigmatic. Here, we overexpressed c-Rel specifically in mouse B cells from BAC-transgenic gene loci and demonstrate that c-Rel protein levels linearly dictated expansion of germinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32191641
DOI: 10.1172/JCI124382
PMCID: PMC7260018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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