Article
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.
Immunity - 20 Mar 2018
Li Xin, Gadzinsky Adeline, Gong Liying, Tong Haijun, Calderon Virginie, Li Yue, Kitamura Daisuke, Klein Ulf, Langdon Wallace Y, Hou Fajian, Zou Yong-Rui, Gu Hua
Abstract excerpt
Selective expansion of high-affinity antigen-specific B cells in germinal centers (GCs) is a key event in antibody affinity maturation. GC B cells with improved affinity can either continue affinity-driven selection or exit the GC to differentiate into plasma cells (PCs) or memory B cells. Here we found that deleting E3 ubiquitin ligases Cbl and Cbl-b (Cbls) in GC B cells resulted in the early exit of...
Topics
- Animals
- Antibody Affinity
- Antibody Formation
- B-Lymphocyte Subsets
- B-Lymphocytes
- Cell Differentiation
- Clonal Selection, Antigen-Mediated
- Gene Expression
- Gene Knockout Techniques
- Germinal Center