Article
Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.
The Journal of experimental medicine - 19 Nov 2012
Espéli Marion, Clatworthy Menna R, Bökers Susanne, Lawlor Kate E, Cutler Antony J, Köntgen Frank, Lyons Paul A, Smith Kenneth G C
Abstract excerpt
Genetic variants of the inhibitory Fc receptor FcγRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown and was investigated by knocking in the most commonly conserved wild mouse Fcgr2b promoter haplotype, also associated with autoimmune-prone mouse strains, into the C57BL/6 background. We...
Topics
- Animals
- Autoantibodies
- Autoimmunity
- B-Lymphocytes
- Chromatin Immunoprecipitation
- DNA Primers
- Enzyme-Linked Immunosorbent Assay
- Enzyme-Linked Immunospot Assay
- Flow Cytometry
- Gene Expression Regulation
- Gene Knock-In Techniques
- Genetic Variation