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Article

Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 2006

Casola Stefano, Cattoretti Giorgio, Uyttersprot Nathalie, Koralov Sergei B, Seagal Jane, Segal Jane, Hao Zhenyue, Waisman Ari, Egert Angela, Ghitza Dvora, Rajewsky Klaus

Abstract excerpt

Germinal centers (GCs) represent the main sites for the generation of high-affinity, class-switched antibodies during T cell-dependent antibody responses. To study gene function specifically in GC B cells, we generated Cgamma1-cre mice in which the expression of Cre recombinase is induced by transcription of the Ig gamma1 constant region gene segment (Cgamma1). In these mice, Cre-mediated recombination at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16651521
DOI: 10.1073/pnas.0602353103
PMCID: PMC1464351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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