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Article

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice

3 Mar 2012

Abstract excerpt

On antigen binding by the B-cell receptor (BCR), B cells up-regulate protein expression of the key downstream signaling molecule Bruton tyrosine kinase (Btk), but the effects of Btk up-regulation on B-cell function are unknown. Here, we show that transgenic mice overexpressing Btk specifically in B cells spontaneously formed germinal centers and manifested increased plasma cell numbers, leading to antinuclear...

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Identifiers

PMID: 22383797
DOI: 10.1182/blood-2011-12-397919

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