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Article

High Intra- and Inter-Tumoral Heterogeneity of RAS Mutations in Colorectal Cancer.

International journal of molecular sciences - 1 Dec 2016

Jeantet Marion, Tougeron David, Tachon Gaelle, Cortes Ulrich, Archambaut Céline, Fromont Gaelle, Karayan-Tapon Lucie

Abstract excerpt

Approximately 30% of patients with wild type RAS metastatic colorectal cancer are non-responders to anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs), possibly due to undetected tumoral subclones harboring RAS mutations. The aim of this study was to analyze the distribution of RAS mutations in different areas of the primary tumor, metastatic lymph nodes and distant metastasis. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27916952
DOI: 10.3390/ijms17122015
PMCID: PMC5187815

Genes

EGFR
BRAF
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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