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Article

Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression.

BMC biology - 7 Sept 2020

Mamlouk Soulafa, Simon Tincy, Tomás Laura, Wedge David C, Arnold Alexander, Menne Andrea, Horst David, Capper David, Morkel Markus, Posada David, Sers Christine, Bläker Hendrik

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) development is generally accepted as a sequential process, with genetic mutations determining phenotypic tumor progression. However, matching genetic profiles with histological transition requires the analyses of temporal samples from the same patient at key stages of progression. RESULTS: Here, we compared the genetic profiles of 34 early carcinomas with their respective...

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Source

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Identifiers

PMID: 32895052
DOI: 10.1186/s12915-020-00844-x
PMCID: PMC7487684

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