Article
Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens.
PloS one - 1 Jan 2015
Vaqué José P, Martínez Nerea, Varela Ignacio, Fernández Fidel, Mayorga Marta, Derdak Sophia, Beltrán Sergi, Moreno Thaidy, Almaraz Carmen, De Las Heras Gonzalo, Bayés Mónica, Gut Ivo, Crespo Javier, Piris Miguel A
Abstract excerpt
We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multiple synchronous colorectal lesions show non overlapping mutational signatures highlighting the degree of heterogeneity between multiple specimens in the same patient....
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