Article
In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2017
Woischke Christine, Schaaf Christian W, Yang Hui-Min, Vieth Michael, Veits Lothar, Geddert Helene, Märkl Bruno, Stömmer Peter, Schaeffer David F, Frölich Matthias, Blum Helmut, Vosberg Sebastian, Greif Philipp A, Jung Andreas, Kirchner Thomas, Horst David
Abstract excerpt
Neuroendocrine carcinomas (NECs) of the colorectum are rare but highly aggressive neoplasms. These tumors show some shared genetic alterations with colorectal adenocarcinomas, and most of them have adjacent glandular adenoma or adenocarcinoma components. However, genetic data on colorectal NECs still are sparse and insufficient for definite conclusions regarding their molecular origin. Based on morphological...
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