Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis.

Biochemical and biophysical research communications - 27 Feb 2015

Kogita Akihiro, Yoshioka Yasumasa, Sakai Kazuko, Togashi Yosuke, Sogabe Shunsuke, Nakai Takuya, Okuno Kiyotaka, Nishio Kazuto

Abstract excerpt

Intra- and inter-tumor heterogeneity may hinder personalized molecular-target treatment that depends on the somatic mutation profiles. We performed mutation profiling of formalin-fixed paraffin embedded tumors of multi-regional colon cancer and characterized the consequences of intra- and inter-t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to Colonic Neoplasms
Share to Paraffin Embedding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to ras Proteins

Share to Receptor, ErbB-4

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Smad4 Protein

Source

Identifiers

PMID: 25623536
DOI: 10.1016/j.bbrc.2015.01.064

Genes

ERBB4
KRAS
SMAD4
APC
FGFR3
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25623536-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis.PMID 25623536Read ↗

Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing.Semantic proximity Read ↗

Research progress on genetic heterogeneity between primary and paired metastatic colorectal cancer.Semantic proximity Read ↗

Comparative analysis of clonal evolution among patients with right-sided colon cancer, left-sided colon cancer and rectal cancerSemantic proximity Read ↗

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.Semantic proximity Read ↗

Proof-of-concept pilot study on comprehensive spatiotemporal intra-patient heterogeneity for colorectal cancer with liver metastasisSemantic proximity Read ↗

Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic developmentSemantic proximity Read ↗

Intratumor Heterogeneity and Evolution of Colorectal CancerSemantic proximity Read ↗

Research progress of colorectal cancer in genomic and transcriptomic at multi-levelSemantic proximity Read ↗

Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures.Semantic proximity Read ↗

Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.Semantic proximity Read ↗

A multiple metastatic colon cancer patient with extra-long survival and acquired BRAF mutation: case report and literature reviewSemantic proximity Read ↗

Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.