Article
Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice.
Scientific reports - 13 Mar 2020
Yang Pan, Wang Youlin, Tang Weiqing, Sun Weiwei, Ma Yinyan, Lin Shu, Jing Jia, Jiang Long, Shi Hang, Song Zhiyuan, Yu Liqing
Abstract excerpt
Humans and rodents with Comparative Gene Identification-58 (CGI-58) mutations manifest nonalcoholic fatty liver disease (NAFLD). Here we show that liver CGI-58 knockout (LivKO) mice fed a Western diet rapidly develop advanced NAFLD, including nonalcoholic steatohepatitis (NASH) and hepatic fibrosis. After 14 weeks of diet challenge, starting at 6 weeks of age, LivKO mice showed increased inflammatory cell...
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