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Article

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways.

Scientific reports - 28 Oct 2021

Paquette Mathieu, Yan Ming, Ramírez-Reyes Josué M J, El-Houjeiri Leeanna, Biondini Marco, Dufour Catherine R, Jeong Hyeonju, Pacis Alain, Giguère Vincent, Estall Jennifer L, Siegel Peter M, Audet-Walsh Étienne, Pause Arnim

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacological agents are currently approved to treat these conditions, but it is clear now that modulation of lipid synthesis and autophagy are key biological mechanisms that could help...

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Identifiers

PMID: 34711912
DOI: 10.1038/s41598-021-99958-7
PMCID: PMC8553785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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