Article

Osteoprotegerin deficiency aggravates methionine- choline- deficient diet-induced nonalcoholic steatohepatitis in mice

2022-11-18

Abstract excerpt

<h4>Background: </h4> & Aims: Clinical studies have shown that osteoprotegerin (OPG) is reduced in patients with nonalcoholic steatohepatitis (NASH), but the underlying mechanisms are unclear. The current study focuses on the role of OPG in the NASH pathogenesis. Methods OPG knockout mice and wild-type control mice fed a methionine choline-deficient diet (MCD) for 4 weeks resulted in an animal model of NASH. Mea...

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Literature Corpus work: 5ac07df1-c177-5fa2-a950-aacdd6322dcf
DOI: 10.21203/rs.3.rs-2261985/v1

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