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Article

Hepatocyte CD36 protects mice from NASH diet-induced liver injury and fibrosis via blocking N1ICD production.

Biochimica et biophysica acta. Molecular basis of disease - 1 Oct 2023

Li Yuqi, Zhang Linkun, Jiao Junkui, Ding Qiuying, Li Yanping, Zhao Zhibo, Luo Jinfeng, Chen Yaxi, Ruan Xiongzhong, Zhao Lei

Abstract excerpt

BACKGROUND & AIMS: Fatty acid translocase CD36 (CD36/FAT) is a widely expressed membrane protein with multiple immuno-metabolic functions. Genetic CD36 deficiency is associated with increased risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients. Liver fibrosis severity mainly affects the prognosis in patients with MAFLD, but the role of hepatocyte CD36 in liver fibrosis of MAFLD...

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PMID: 37423141
DOI: 10.1016/j.bbadis.2023.166800

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