Article

Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma

2023-11-15

Abstract excerpt

Obesity-linked fatty liver is a significant risk factor for hepatocellular carcinoma (HCC) 1,2 ; however, the molecular mechanisms underlying the transition from non-alcoholic fatty liver disease (NAFLD) to HCC remains unclear. The present study explores the role of the endoplasmic reticulum (ER)-associated protein NgBR, an essential component of the cis-prenyltransferases (cis-PTase) enzyme 3 , in chronic liver...

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Literature Corpus work: 7caba8a4-3950-5492-b1e7-00e112c21d12
DOI: 10.1101/2023.11.13.566870

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Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinomaDOI 10.1101/2023.11.13.566870Read

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