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Article

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.

Journal of hepatology - 1 Oct 2020

Schwerbel Kristin, Kamitz Anne, Krahmer Natalie, Hallahan Nicole, Jähnert Markus, Gottmann Pascal, Lebek Sandra, Schallschmidt Tanja, Arends Danny, Schumacher Fabian, Kleuser Burkhard, Haltenhof Tom, Heyd Florian, Gancheva Sofiya, Broman Karl W, Roden Michael, Joost Hans-Georg, Chadt Alexandra, Al-Hasani Hadi, Vogel Heike, Jonas Wenke, Schürmann Annette

Abstract excerpt

BACKGROUND & AIMS: Currently, only a few genetic variants explain the heritability of fatty liver disease. Quantitative trait loci (QTL) analysis of mouse strains has identified the susceptibility locus Ltg/NZO (liver triglycerides from New Zealand obese [NZO] alleles) on chromosome 18 as associating with increased hepatic triglycerides. Herein, we aimed to identify genomic variants responsible for this...

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Identifiers

PMID: 32376415
DOI: 10.1016/j.jhep.2020.04.031
PMCID: PMC7957830

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