Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clusterin overexpression protects against western diet-induced obesity and NAFLD.

Scientific reports - 15 Oct 2020

Park Jin-Sung, Lee Woon-Kyu, Kim Hyeon Soo, Seo Ji A, Kim Dong-Hoon, Han Hee Chul, Min Bon-Hong

Abstract excerpt

Obesity is a significant risk factor for various metabolic diseases and is closely related to non-alcoholic fatty liver disease (NAFLD) characterized by inflammation and oxidative stress. Clusterin is a multi-functional protein that is up-regulated in the pathogenesis of various metabolic diseases, including obesity and NAFLD. Our previous studies indicated that hepatocyte-specific overexpression of clusterin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clusterin

Share to Cytosol

Share to Diet, Western

Share to NF-E2-Related Factor 2

Share to Non-alcoholic Fatty Liver Disease

Share to Oxidative Stress

Source

Open in PubMed Open full text

Identifiers

PMID: 33060605
DOI: 10.1038/s41598-020-73927-y
PMCID: PMC7562726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clusterin overexpression protects against western diet-induced obesity and NAFLD.PMID 33060605Read ↗

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.Semantic proximity Read ↗

Effects of Nutritionally Induced Obesity on Metabolic Pathways of ZebrafishSemantic proximity Read ↗

Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in miceSemantic proximity Read ↗

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver diseaseSemantic proximity Read ↗

Transcriptome and translatome analyses reveal the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosisSemantic proximity Read ↗

Establishment of animal models for NASH and utilization for mining associated gut microbiotaSemantic proximity Read ↗

Fat Mass and Obesity–Associated Protein Promotes Liver Steatosis By Targeting PPARαSemantic proximity Read ↗

Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in MiceSemantic proximity Read ↗

Calorie restriction and life-extending mutation downregulate miR-34a to facilitate lipid metabolism in the liver.Semantic proximity Read ↗

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways.Semantic proximity Read ↗

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma.Semantic proximity Read ↗

Time-restricted feeding ameliorates MCDD-induced steatohepatitis in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.