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Article

Efficient SNP editing in haploid human pluripotent stem cells.

Journal of assisted reproduction and genetics - 1 Apr 2020

Safier Lauren Zakarin, Zuccaro Michael V, Egli Dietrich

Abstract excerpt

PURPOSE: To correct a potentially damaging mutation in haploid human embryonic stem cells. METHODS: Exome sequencing was performed on DNA extracted from parthenogenetically derived embryonic stem cell line (pES12). An SLC10A2 gene mutation, which affects bile acid transport, was chosen as mutation of interest in this proof of concept study to attempt correction in human pluripotent haploid cells. Confirmation of...

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Identifiers

PMID: 32162131
DOI: 10.1007/s10815-020-01723-8
PMCID: PMC7183036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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