Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex.

Nature communications - 13 Sept 2024

Wu Yue, Zhang Qiongdan, Lin Yuhan, Lam Wai Hei, Zhai Yuanliang

Abstract excerpt

In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing. Here we show that the N-terminal intrinsically disordered region (IDR) of the yeast Orc2 subunit is crucial for this process. Removing a segment (residues 176-200) from Orc2-IDR or mutating a key isoleucine (194) significantly inhibits replication initiation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to G1 Phase

Share to Intrinsically Disordered Proteins

Share to Origin Recognition Complex

Share to Replication Origin

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39271725
DOI: 10.1038/s41467-024-52408-0
PMCID: PMC11399261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex.PMID 39271725Read ↗

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication.Semantic proximity Read ↗

Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences.Semantic proximity Read ↗

Evolution of DNA replication origin specification and gene silencing mechanisms.Semantic proximity Read ↗

Humanizing the yeast origin recognition complex.Semantic proximity Read ↗

ORC1 binds to <i>cis</i> -transcribed RNAs for efficient activation of replication originsSemantic proximity Read ↗

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Semantic proximity Read ↗

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.Semantic proximity Read ↗

The origin recognition complex in human diseases.Semantic proximity Read ↗

Two subunits of human ORC are dispensable for DNA replication and proliferationSemantic proximity Read ↗

Orc6 is a component of the replication fork and enables efficient mismatch repairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.