Article
Eucaryotic replication origin binding proteins.
Frontiers in bioscience : a journal and virtual library - 1 Sept 2004
Zannis-Hadjopoulos Maria, Sibani Sahar, Price Gerald B
Abstract excerpt
Initiation of eukaryotic DNA replication is a tightly controlled process. Replication initiates at multiple specific sites (replication origins) that have been licensed for replication, following the cell cycle-dependent, multi-step assembly of specific factors. Thus, replication origins occur in two chromatin states: a replication-competent pre-replicative (pre-RC) state, when a number of replication proteins...
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