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Article

The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates.

Nucleic acids research - 17 Apr 2020

Çağlayan Melike

Abstract excerpt

DNA ligase I and DNA ligase III/XRCC1 complex catalyze the ultimate ligation step following DNA polymerase (pol) β nucleotide insertion during base excision repair (BER). Pol β Asn279 and Arg283 are the critical active site residues for the differentiation of an incoming nucleotide and a template base and the N-terminal domain of DNA ligase I mediates its interaction with pol β. Here, we show inefficient ligation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32140717
DOI: 10.1093/nar/gkaa151
PMCID: PMC7144901

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