Article

Structural and biochemical characterization of LIG1 during mutagenic nick sealing of oxidatively damaged ends at the final step of DNA repair

2024-05-06

Abstract excerpt

DNA ligase 1 (LIG1) joins broken strand-breaks in the phosphodiester backbone to finalize DNA repair pathways. We previously reported that LIG1 fails on nick repair intermediate with 3’-oxidative damage incorporated by DNA polymerase (pol) β at the downstream steps of base excision repair (BER) pathway. Here, we determined X-ray structures of LIG1/nick DNA complexes containing 3’-8oxodG and 3’-8oxorG opposite eith...

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Literature Corpus work: 4355b8a3-f36b-5e37-b5ca-13ec8661ceac
DOI: 10.1101/2024.05.06.592774

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