Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis.

doi:10.1016/j.dnarep.2010.09.005

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Article

Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis.

DNA repair - 2 Jan 2011

Brown Jessica A, Pack Lindsey R, Sanman Laura E, Suo Zucai

Abstract excerpt

The base excision repair (BER) pathway coordinates the replacement of 1-10 nucleotides at sites of single-base lesions. This process generates DNA substrates with various gap sizes which can alter the catalytic efficiency and fidelity of a DNA polymerase during gap-filling DNA synthesis. Here, we quantitatively determined the substrate specificity and base substitution fidelity of human DNA polymerase λ (Pol λ),...

Topics

Amino Acid Motifs
Base Sequence
DNA
DNA Polymerase beta
DNA Repair
Deoxyribonucleotides
Humans
Kinetics
Mutation
Substrate Specificity

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Identifiers

PMID: 20961817
DOI: 10.1016/j.dnarep.2010.09.005
PMCID: PMC3065367

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