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The endonuclease domain of MutL interacts with the β sliding clamp.

DNA repair - 2 Jan 2011

Pillon Monica C, Miller Jeffrey H, Guarné Alba

Abstract excerpt

Mismatch repair corrects errors that have escaped polymerase proofreading enhancing replication fidelity by at least two orders of magnitude. The β and PCNA sliding clamps increase the polymerase processivity during DNA replication and are important at several stages of mismatch repair. Both MutS and MutL, the two proteins that initiate the mismatch repair response, interact with β. Binding of MutS to β is...

Topics

Adenosine Triphosphatases
Amino Acid Motifs
Amino Acid Sequence
Bacillus subtilis
Consensus Sequence
DNA Mismatch Repair
DNA Polymerase III
Endonucleases
Escherichia coli
Escherichia coli Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MutL Proteins

Mutation

Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 21050827
DOI: 10.1016/j.dnarep.2010.10.003
PMCID: PMC3028594

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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