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Article

High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.

Nature communications - 20 Jan 2021

Williams Jessica S, Tumbale Percy P, Arana Mercedes E, Rana Julian A, Williams R Scott, Kunkel Thomas A

Abstract excerpt

DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly discriminate against incorrectly paired DNA substrates. Whether intrinsic ligation fidelity contributes to the accuracy of replication of the nuclear genome is unknown. Here, we show that an engineered low-fidelity LIG1Cdc9 variant confers a novel mutator...

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Identifiers

PMID: 33473124
DOI: 10.1038/s41467-020-20800-1
PMCID: PMC7817679

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