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Article

Beyond Short Microhomologies: Mismatch-Compatible Pol θ-Mediated DNA Damage Repair.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Mar 2026

Li Yuzhen, Wood Richard D

Abstract excerpt

DNA polymerase θ (Pol θ)-mediated end-joining (TMEJ), one of several pathways for repairing DNA double-strand breaks, is traditionally thought to initiate via anchoring at short, consecutive, and perfectly matched microhomologies (MHs). Emerging evidence indicates that Pol θ can utilize MHs containing mismatches both in vitro and in vivo. This revised definition of MH provides a mechanistic explanation for a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41879469
DOI: 10.1002/bies.70129
PMCID: PMC13015775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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