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Article

DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair.

The Journal of biological chemistry - 1 Jan 2000

Kamble Pradnya, Hall Kalen, Chandak Mahesh, Tang Qun, Çağlayan Melike

Abstract excerpt

DNA ligase I (LIG1) completes the base excision repair (BER) pathway at the last nick-sealing step after DNA polymerase (pol) β gap-filling DNA synthesis. However, the mechanism by which LIG1 fidelity mediates the faithful substrate-product channeling and ligation of repair intermediates at the final steps of the BER pathway remains unclear. We previously reported that pol β 8-oxo-2'-deoxyribonucleoside...

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Identifiers

PMID: 33600799
DOI: 10.1016/j.jbc.2021.100427
PMCID: PMC8024709

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