Article

Structures of LIG1 uncover a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA

2022-09-27

Abstract excerpt

<title>Abstract</title> <p>Ribonucleotides can be incorporated by DNA polymerases and the subsequent joining of 3'-OH and 5'-P ends in the phosphodiester backbone at the nick by DNA ligase during DNA replication and repair is critical for maintaining genome stability. Although it has been extensively studied for DNA polymerases across families, the sugar discrimination mechanism of a human DNA ligase at atomic re...

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Literature Corpus work: 73fa0b89-4aa4-5be6-a06a-c1e5afc51d18
DOI: 10.21203/rs.3.rs-1998177/v1

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