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DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage.

Mutagenesis - 1 Dec 2020

Tang Qun, Kamble Pradnya, Çağlayan Melike

Abstract excerpt

DNA ligase I (LIG1) joins DNA strand breaks during DNA replication and repair transactions and contributes to genome integrity. The mutations (P529L, E566K, R641L and R771W) in LIG1 gene are described in patients with LIG1-deficiency syndrome that exhibit immunodeficiency. LIG1 senses 3'-DNA ends with a mismatch or oxidative DNA base inserted by a repair DNA polymerase. However, the ligation efficiency of the...

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Identifiers

PMID: 32914844
DOI: 10.1093/mutage/geaa023
PMCID: PMC7846189

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