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Article

Export of a single drug molecule in two transport cycles by a multidrug efflux pump.

Nature communications - 8 Aug 2014

Fluman Nir, Adler Julia, Rotenberg Susan A, Brown Melissa H, Bibi Eitan

Abstract excerpt

Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug transporter MdfA exchanges a single proton with a single monovalent cationic drug molecule. This stoichiometry renders the efflux of divalent cationic drugs energetically unfavourable, as it requires exchange with at least two protons. Here we show that...

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Identifiers

PMID: 25105370
DOI: 10.1038/ncomms5615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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