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Article

A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter.

Journal of molecular biology - 27 Apr 2018

Zomot Elia, Yardeni Eliane Hadas, Vargiu Attilio Vittorio, Tam Heng-Keat, Malloci Giuliano, Ramaswamy Venkata Krishnan, Perach Michal, Ruggerone Paolo, Pos Klaas Martinus, Bibi Eitan

Abstract excerpt

Secondary multidrug (Mdr) transporters utilize ion concentration gradients to actively remove antibiotics and other toxic compounds from cells. The model Mdr transporter MdfA from Escherichia coli exchanges dissimilar drugs for protons. The transporter should open at the cytoplasmic side to enable access of drugs into the Mdr recognition pocket. Here we show that the cytoplasmic rim around the Mdr recognition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29530612
DOI: 10.1016/j.jmb.2018.02.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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