Article
Molecular mechanism of ligand recognition by membrane transport protein, Mhp1.
The EMBO journal - 18 Aug 2014
Simmons Katie J, Jackson Scott M, Brueckner Florian, Patching Simon G, Beckstein Oliver, Ivanova Ekaterina, Geng Tian, Weyand Simone, Drew David, Lanigan Joseph, Sharples David J, Sansom Mark S P, Iwata So, Fishwick Colin W G, Johnson A Peter, Cameron Alexander D, Henderson Peter J F
Abstract excerpt
The hydantoin transporter Mhp1 is a sodium-coupled secondary active transport protein of the nucleobase-cation-symport family and a member of the widespread 5-helix inverted repeat superfamily of transporters. The structure of Mhp1 was previously solved in three different conformations providing insight into the molecular basis of the alternating access mechanism. Here, we elucidate detailed events of substrate...
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