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Article

Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions.

Scientific reports - 5 Dec 2016

Nair Asha V, Singh Himansha, Raturi Sagar, Neuberger Arthur, Tong Zhen, Ding Ning, Agboh Kelvin, van Veen Hendrik W

Abstract excerpt

The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents. These transporters reduce intracellular drug concentrations to subtoxic levels by mediating drug efflux across the cell envelope. The major facilitator superfamily multidrug transporter LmrP from Lactococcus lactis catalyses drug efflux in...

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PMID: 27917857
DOI: 10.1038/srep38052
PMCID: PMC5137110

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