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Article

Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2010

Li Fubin, Yan Yi, Pieretti Joyce, Feldman Danielle A, Eckhardt Laurel A

Abstract excerpt

Somatic hypermutation (SHM), coupled with Ag selection, provides a mechanism for generating Abs with high affinity for invading pathogens. Class-switch recombination (CSR) ensures that these Abs attain pathogen-appropriate effector functions. Although the enzyme critical to both processes, activation-induced cytidine deaminase, has been identified, it remains unclear which cis-elements within the Ig loci are...

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Share to Cell Separation
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Flow Cytometry

Share to Gene Knock-In Techniques

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunoglobulin Class Switching

Share to Somatic Hypermutation, Immunoglobulin

Source

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Identifiers

PMID: 20937850
DOI: 10.4049/jimmunol.0902992
PMCID: PMC3280099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.PMID 20937850Read ↗

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cellsSemantic proximity Read ↗

Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Semantic proximity Read ↗

Roles of the Ig κ Light Chain Intronic and 3′ Enhancers in Igk Somatic HypermutationSemantic proximity Read ↗

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.Semantic proximity Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation.Semantic proximity Read ↗

Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Semantic proximity Read ↗

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.Semantic proximity Read ↗

The IgH <i>Eμ</i> -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutationSemantic proximity Read ↗

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Semantic proximity Read ↗

A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.Semantic proximity Read ↗

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