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Article

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

1 Jul 2013

Abstract excerpt

Interactions with cognate antigens recruit activated B cells into germinal centers where they undergo somatic hypermutation (SHM) in V(D)J exons for the generation of high-affinity antibodies. The contribution of IgH transcriptional enhancers in SHM is unclear. The Eμ enhancer upstream of Cμ has a marginal role, whereas the influence of the IgH 3' regulatory region (3'RR) enhancers (hs3a, hs1,2, hs3b, and hs4) is...

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PMID: 23825188
DOI: 10.1084/jem.20130072

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