Article

The IgH <i>Eμ</i> -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

2022-08-16

Abstract excerpt

Two scaffold/matrix attachment regions (5’- and 3’- MARs Eμ ) flank the intronic core enhancer (c Eμ ) within the immunoglobulin heavy chain locus ( IgH ). Besides their conservation in mice and humans, the physiological role of MARs Eμ is still unclear and their involvement in somatic hypermutation (SHM) has never been deeply evaluated. By analysing a mouse model devoid of MARs Eμ , we observed an inverted s...

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Literature Corpus work: 3c2bc02d-fc0c-52d2-9732-891a5398701b
DOI: 10.1101/2022.08.15.503996

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