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Article

Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells.

Genome biology - 21 Feb 2020

Zhang Tiantian, Zhang Zhuqiang, Dong Qiang, Xiong Jun, Zhu Bing

Abstract excerpt

H3K27ac is well recognized as a marker for active enhancers and a great indicator of enhancer activity. However, its functional impact on transcription has not been characterized. By substituting lysine 27 in histone variant H3.3 with arginine in mouse embryonic stem cells, we diminish the vast majority of H3K27ac at enhancers. However, the transcriptome is largely undisturbed in these mutant cells, likely...

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Identifiers

PMID: 32085783
DOI: 10.1186/s13059-020-01957-w
PMCID: PMC7035716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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