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Article

Histone H3.3 lysine 9 and 27 control repressive chromatin at cryptic enhancers and bivalent promoters.

Nature communications - 30 Aug 2024

Trovato Matteo, Bunina Daria, Yildiz Umut, Fernandez-Novel Marx Nadine, Uckelmann Michael, Levina Vita, Perez Yekaterina, Janeva Ana, Garcia Benjamin A, Davidovich Chen, Zaugg Judith B, Noh Kyung-Min

Abstract excerpt

Histone modifications are associated with distinct transcriptional states, but it is unclear whether they instruct gene expression. To investigate this, we mutate histone H3.3 K9 and K27 residues in mouse embryonic stem cells (mESCs). Here, we find that H3.3K9 is essential for controlling specific distal intergenic regions and for proper H3K27me3 deposition at promoters. The H3.3K9A mutation resulted in decreased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39214979
DOI: 10.1038/s41467-024-51785-w
PMCID: PMC11364623

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