Article
Enhancer requirement for histone methylation linked with gene activation.
The FEBS journal - 1 Dec 2008
Rentoft Matilda, Kim Kihoon, Cho Youngran, Lee Choon-Hwan, Kim Aeri
Abstract excerpt
Enhancers cause a high level of transcription and activation of chromatin structure at target genes. Hyperacetylation of histones H3 and H4, a mark of active chromatin, is established broadly across target loci by enhancers that function over long distances. In the present study, we studied the r...
Topics
- Binding Sites
- Chromatin Immunoprecipitation
- Enhancer Elements, Genetic
- Histones
- Humans
- K562 Cells
- Lysine
- Methylation
- Mutation
- NF-E2 Transcription Factor, p45 Subunit
- Nucleosomes