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Article

Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB.

Human molecular genetics - 27 Jun 2020

Bicak Mesude, Wang Xing, Gao Xiaoni, Xu Xing, Väänänen Riina-Minna, Taimen Pekka, Lilja Hans, Pettersson Kim, Klein Robert J

Abstract excerpt

How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel cis-eQTLs and trans-eQTLs. Mediation testing and colocalization analysis demonstrate that MSMB is a cis-acting mediator for SNHG11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32065238
DOI: 10.1093/hmg/ddaa026
PMCID: PMC7526792

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