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Article

DNA methylation and cis-regulation of gene expression by prostate cancer risk SNPs.

PLoS genetics - 1 Mar 2020

Dai James Y, Wang Xiaoyu, Wang Bo, Sun Wei, Jordahl Kristina M, Kolb Suzanne, Nyame Yaw A, Wright Jonathan L, Ostrander Elaine A, Feng Ziding, Stanford Janet L

Abstract excerpt

Genome-wide association studies have identified more than 100 SNPs that increase the risk of prostate cancer (PrCa). We identify and compare expression quantitative trait loci (eQTLs) and CpG methylation quantitative trait loci (meQTLs) among 147 established PrCa risk SNPs in primary prostate tumors (n = 355 from a Seattle-based study and n = 495 from The Cancer Genome Atlas, TCGA) and tumor-adjacent,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32226005
DOI: 10.1371/journal.pgen.1008667
PMCID: PMC7145271

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