Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.

doi:10.1371/journal.pgen.1001204

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Article

Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.

PLoS genetics - 11 Nov 2010

Pomerantz Mark M, Shrestha Yashaswi, Flavin Richard J, Regan Meredith M, Penney Kathryn L, Mucci Lorelei A, Stampfer Meir J, Hunter David J, Chanock Stephen J, Schafer Eric J, Chan Jennifer A, Tabernero Josep, Baselga José, Richardson Andrea L, Loda Massimo, Oh William K, Kantoff Philip W, Hahn William C, Freedman Matthew L

Abstract excerpt

Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding region, the target genes driving tumorigenesis are not readily apparent. Two genes nearest to...

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Identifiers

PMID: 21085629
DOI: 10.1371/journal.pgen.1001204
PMCID: PMC2978684

Genes

MSMB
NCOA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21085629-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.PMID 21085629Read ↗

Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.Semantic proximity Read ↗

Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk.Semantic proximity Read ↗

Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.Semantic proximity Read ↗

Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.Semantic proximity Read ↗

Validation of prostate cancer risk variants by CRISPR/Cas9 mediated genome editingSemantic proximity Read ↗

Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer.Semantic proximity Read ↗

The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.Semantic proximity Read ↗

Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.Semantic proximity Read ↗

Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB.Semantic proximity Read ↗

Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer.Semantic proximity Read ↗

A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.Semantic proximity Read ↗

MSMB gene rs10993994 polymorphism increases the risk of prostate cancer.Semantic proximity Read ↗

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