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The Impact of Inherited Genetic Variation on DNA Methylation in Prostate Cancer and Benign Tissues of African American and European American Men.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Apr 2024

Delgado Dayana, Gillard Marc, Tong Lin, Demanelis Kathryn, Oliva Meritxell, Gleason Kevin J, Chernoff Meytal, Chen Lin, Paner Gladell P, Vander Griend Donald, Pierce Brandon L

Abstract excerpt

BACKGROUND: American men of African ancestry (AA) have higher prostate cancer incidence and mortality rates compared with American men of European ancestry (EA). Differences in genetic susceptibility mechanisms may contribute to this disparity. METHODS: To gain insights into the regulatory mechanisms of prostate cancer susceptibility variants, we tested the association between SNPs and DNA methylation (DNAm) at...

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PMID: 38294689
DOI: 10.1158/1055-9965.EPI-23-0849
PMCID: PMC10990789

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