Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

doi:10.1016/j.ccell.2019.10.005

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Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

Cancer cell - 9 Dec 2019

Mazrooei Parisa, Kron Ken J, Zhu Yanyun, Zhou Stanley, Grillo Giacomo, Mehdi Tahmid, Ahmed Musaddeque, Severson Tesa M, Guilhamon Paul, Armstrong Nicholas Sinnott, Huang Vincent, Yamaguchi Takafumi N, Fraser Michael, van der Kwast Theodorus, Boutros Paul C, He Housheng Hansen, Bergman Andries M, Bristow Robert G, Zwart Wilbert, Lupien Mathieu

Abstract excerpt

Thousands of noncoding somatic single-nucleotide variants (SNVs) of unknown function are reported in tumors. Partitioning the genome according to cistromes reveals the enrichment of somatic SNVs in prostate tumors as opposed to adjacent normal tissue cistromes of master transcription regulators, including AR, FOXA1, and HOXB13. This parallels enrichment of prostate cancer genetic predispositions over these...

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PMID: 31735626
DOI: 10.1016/j.ccell.2019.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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