Article

Validation of prostate cancer risk variants by CRISPR/Cas9 mediated genome editing

2018-06-01

Abstract excerpt

GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP is rs10993994. It is located in the MSMB promoter, associates with MSMB encoded β-microseminoprotein prostate secretion levels, and is associated with mRNA expression changes in MSMB and the adjacent gene NCOA4. In addition, our previous work showed a second SNP, rs7098889, is in LD with rs10993994 and associated with MSMB e...

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Literature Corpus work: 41be47b0-0230-5bee-90ba-d5a8d0851122
DOI: 10.1101/337022

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Validation of prostate cancer risk variants by CRISPR/Cas9 mediated genome editingDOI 10.1101/337022Read

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