Article
Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk.
Human molecular genetics - 1 Apr 2009
Chang Bao-Li, Cramer Scott D, Wiklund Fredrik, Isaacs Sarah D, Stevens Victoria L, Sun Jielin, Smith Shelly, Pruett Kristen, Romero Lina M, Wiley Kathleen E, Kim Seong-Tae, Zhu Yi, Zhang Zheng, Hsu Fang-Chi, Turner Aubrey R, Adolfsson Jan, Liu Wennuan, Kim Jin Woo, Duggan David, Carpten John, Zheng S Lilly, Rodriguez Carmen, Isaacs William B, Grönberg Henrik, Xu Jianfeng
Abstract excerpt
A single nucleotide polymorphism (SNP) at 10q11 (rs10993994) in the 5' region of the MSMB gene was recently implicated in prostate cancer risk in two genome-wide association studies. To identify possible causal variants in the region, we genotyped 16 tagging SNPs and imputed 29 additional SNPs in approximately 65 kb genomic region at 10q11 in a Swedish population-based case-control study (CAncer of the Prostate...
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