Article
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.
Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009
Lou Hong, Yeager Meredith, Li Hongchuan, Bosquet Jesus Gonzalez, Hayes Richard B, Orr Nick, Yu Kai, Hutchinson Amy, Jacobs Kevin B, Kraft Peter, Wacholder Sholom, Chatterjee Nilanjan, Feigelson Heather Spencer, Thun Michael J, Diver W Ryan, Albanes Demetrius, Virtamo Jarmo, Weinstein Stephanie, Ma Jing, Gaziano J Michael, Stampfer Meir, Schumacher Fredrick R, Giovannucci Edward, Cancel-Tassin Geraldine, Cussenot Olivier, Valeri Antoine, Andriole Gerald L, Crawford E David, Anderson Stephen K, Tucker Margaret, Hoover Robert N, Fraumeni Joseph F, Thomas Gilles, Hunter David J, Dean Michael, Chanock Stephen J
Abstract excerpt
Two recent genome-wide association studies have independently identified a prostate cancer susceptibility locus on chromosome 10q11.2. The most significant single-nucleotide polymorphism (SNP) marker reported, rs10993994, is 57 bp centromeric of the first exon of the MSMB gene, which encodes beta-microseminoprotein (prostatic secretory protein 94). In this study, a fine-mapping analysis using HapMap SNPs was...
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