Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics.

doi:10.1016/j.ebiom.2024.105168

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics.

EBioMedicine - 1 Jul 2024

Desai Trishna A, Hedman Åsa K, Dimitriou Marios, Koprulu Mine, Figiel Sandy, Yin Wencheng, Johansson Mattias, Watts Eleanor L, Atkins Joshua R, Sokolov Aleksandr V, Schiöth Helgi B, Gunter Marc J, Tsilidis Konstantinos K, Martin Richard M, Pietzner Maik, Langenberg Claudia, Mills Ian G, Lamb Alastair D, Mälarstig Anders, Key Tim J, Travis Ruth C, Smith-Byrne Karl

Abstract excerpt

BACKGROUND: Understanding the role of circulating proteins in prostate cancer risk can reveal key biological pathways and identify novel targets for cancer prevention. METHODS: We investigated the association of 2002 genetically predicted circulating protein levels with risk of prostate cancer overall, and of aggressive and early onset disease, using cis-pQTL Mendelian randomisation (MR) and colocalisation....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Mendelian Randomization Analysis

Share to Odds Ratio

Share to Prostatic Neoplasms

Share to Proteome

Share to Proteomics

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 38878676
DOI: 10.1016/j.ebiom.2024.105168
PMCID: PMC11233900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics.PMID 38878676Read ↗

Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using Mendelian randomization and tumor spatial transcriptomicsSemantic proximity Read ↗

Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian RandomizationSemantic proximity Read ↗

Uncovering somatic genetic drivers in prostate cancer through comprehensive genome-wide analysis.Semantic proximity Read ↗

Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer RiskSemantic proximity Read ↗

Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanismsSemantic proximity Read ↗

Associations between genetically predicted concentrations of plasma proteins and the risk of prostate cancer.Semantic proximity Read ↗

Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development.Semantic proximity Read ↗

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical TrajectoriesSemantic proximity Read ↗

Multi-omics association study identifies new potential prostate cancer- causing geneSemantic proximity Read ↗

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.Semantic proximity Read ↗

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.Semantic proximity Read ↗

Proteome-wide association study of prostate cancer risk across populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.